منابع مشابه
Performance of novel kidney biomarkers in preclinical toxicity studies.
The kidney is one of the main targets of drug toxicity, but early detection of renal damage is often difficult. As part of the InnoMed PredTox project, a collaborative effort aimed at assessing the value of combining omics technologies with conventional toxicology methods for improved preclinical safety assessment, we evaluated the performance of a panel of novel kidney biomarkers in preclinica...
متن کاملDrug-induced kidney diseases.
Drug-induced kidney disease constitutes an important cause of acute renal failure and chronic kidney disease in present day clinical practice. Different classes of drugs, by virtue of immunological mechanisms or direct toxicity initiate certain stereotyped renal responses. For most patients suffering from drug-induced nephropathy common risk factors which precipitate the adverse effects include...
متن کامل7. Drug-Induced Kidney Injury
Acute kidney injury is an independent risk factor for patient mortality, even with small decrements in kidney function. In addition, it increases length of stay in the hospital and increases cost of treatment. Renal injury is often multifactorial, with drugs being only one of the factors in its pathogenesis. Hence, it is often difficult to estimate involvement of drugs as a cause of acute kidne...
متن کاملRadiation-induced acute kidney toxicity: Protective effect of L-carnitine versus amifostine
Background: The aim of the study was to compare the radioprotective efficacy in the kidney of L-carnitine to that of amifostine. Materials and Methods: Thirty three-month-old Wistar albino rats were randomly assigned to four groups: Group 1 (Control); Group 2 (Irradiation alone); Group 3 (amifostine plus irradiation); and Group 4 (L-carnitine before irradiation). The rats in Groups 2, 3, ...
متن کاملBiomarkers for drug-induced liver injury.
Of the estimated 10,000 documented human drugs, more than 1000 have been associated with drug-induced liver injury (DILI), although causality has not always been established clearly. Numerous biomarkers for DILI have been explored, but less than ten are adopted or qualified as valid by the US FDA. The biomarkers for DILI are individual or a panel of proteins, nucleic acids or metabolites from v...
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ژورنال
عنوان ژورنال: Therapeutic Drug Monitoring
سال: 2019
ISSN: 0163-4356
DOI: 10.1097/ftd.0000000000000589